Research Detail
December 2024
Our collaborative paper was published in Nucleic Acid Research.
Berardi A*, Kaestner CL*, Ghitti M*, Quilici G, Cocomazzi P, Li J, Ballabio F, Zucchelli C, Knapp S, Licht JD, Musco G. The C-terminal PHDVC5HCH tandem domain of NSD2 is a combinatorial reader of unmodified H3K4 and tri-methylated H3K27 that regulates transcription of cell adhesion genes in multiple myeloma. Nucleic Acids Research. 2024 Dec 5; https://doi.org/10.1093/nar/gkae1121.
November 2024
Jianping joined the CHOP Research Institute Normal and Malignant Hematopoiesis Research Affinity Group (RAG) and presented our research findings about NSD2 mutation in relapsed ALL.
Congratulations to Jianping on receiving The W. W. Smith Charitable Trust (the Trust) grant to support the research project “Novel biomarker of NSD2 mutation-driven acute lymphoblastic leukemia”!
October 2024
Congratulations to Jianping on receiving the American Cancer Society Institutional Research Grant (ACS-IRG) to support the research on the role of NSD2 mutation in ALL!
September 2024
Welcome Venkata (Siva) Dasuri, MD student, to join the lab. Siva is in the Academic Program- Combined BS/MD 7-year program. He just received his bachelor’s degree from Penn State University and joined Thomas Jefferson University Sidney Kimmel Medical College in July 2024. Siva also had a one-year research internship at the Boston Children’s Hospital. Welcome Siva!
Welcome Brianna Gipson, MD student, to join the lab. Brianna received her Bachelor of Science in Biological Sciences (High Honors) at Lehigh University in 2021. She then had 3 years of research experience at the Memorial Sloan Kettering Cancer Center. Brianna joined Thomas Jefferson University Sidney Kimmel Medical College in July 2024. Welcome Brianna!
August 2024
Welcome Seung Hyen Eun, Postbaccalaureate, to join the lab. Seung received his bachelor’s degree in Operations Research and Information Engineering at Cornell University. He is a Postbaccalaureate Pre-Professional Program (P4) student at Jefferson College of Life Sciences. Welcome Seung!
July 2024
Welcome Sihem Nadour, Undergraduate Student, to join the lab. Sihem recently graduated with a major in Biotechnology from Montgomery County Community College and joined Dr. Li’s Lab in July 2024. She is currently planning to pursue her bachelor’s degree at Thomas Jefferson University and focusing on targeting therapy in NSD2 mutant acute lymphoblastic leukemia. Welcome Sihem!
Our first collaborative paper was published in Nature Chemical Biology.
Nie DY*, Tabor JR*, Li J, Kutera M, St-Germain J, Hanley RP, Wolf EZ, Paulakonis E, Kenney TMG, Duan S, Shrestha S, Owens DDG, Pon A, Szewczyk M, Lamberto AJ, Menes M, Li F, Barsyte-Lovejoy D, Brown NG, Barsotti AM, Stamford AW, Collins JL, Wilson DJ, Raught B, Licht J, James L, Arrowsmith C. Recruitment of FBXO22 for Targeted Degradation of NSD2. Nat Chem Biol. 2024 Jul 4. doi: 10.1038/s41589-024-01660-y. Online ahead of print.
Our collaborative paper was published in Blood.
Dupere-Richer D, Riva A, Barwick BG, Maji S, Casellas Roman H, Li J, De U, Sobh A, Quickstad G, Piper C, Kulis M, Ezponda T, Martín-Subero JI, Tonon G, Zhang W, Mitsiades CS, Boise LH, Bennett RL, Licht JD. KDM6A Regulates Immune Response Genes in Multiple Myeloma. Blood. 2024 Jul 24: blood.2024024518. Online ahead of print.
June 2024
Welcome Joseph (Todd) Fredericks, Undergraduate Student, to join the lab. Todd joined Dr. Li’s lab in June 2024 through a biomedical training program at The Wistar Institute. He is currently in the Jefferson College of Health Professionals at Thomas Jefferson University, where he is earning his BS and MS in biotechnology and focusing on NSD2 mutation in acute lymphoblastic leukemia. Welcome Todd!
Congratulations to Jianping on receiving the Charles W. Hevner Memorial Fund Award!
April 2024
Welcome Tian Yuan, our first postdoc fellow, to join the lab. Tian obtained her M.D. at Central South University in 2010 and her Ph.D. in Hematology from Peking Union Medical College in 2013. She received postdoctoral training for about two years at MD Anderson Cancer Center and became very skillful at molecular and cellular biological experiments. Welcome Tian!
March 2024
Dr. Jianping Li was invited to present his lab work at the Next epiGEN Series at Fox Chase Cancer Center, with the topic “Histone methylation and glucocorticoid resistance in relapsed acute lymphoblastic leukemia.”
December 2023
Welcome Zongxiu (Lisa) Zhang, our first lab member, to join the lab. Lisa has been working at Thomas Jefferson University for more than ten years. She has expertise in animal experiments and genotyping, cell culture, DNA, RNA, protein extraction, real-time PCR, western blot, histology, and molecular cloning. Welcome Lisa!
November 2023
Our first collaborative paper at TJU is online on bioRxiv.
Nie DY*, Tabor JR*, Li J, Kutera M, St-Germain J, Hanley RP, Wolf EZ, Paulakonis E, Kenney TMG, Duan S, Shrestha S, Owens DDG, Pon A, Szewczyk M, Lamberto AJ, Menes M, Li F, Barsyte-Lovejoy D, Brown NG, Barsotti AM, Stamford AW, Collins JL, Wilson DJ, Raught B, Licht J, James L, Arrowsmith C. Recruitment of FBXO22 for Targeted Degradation of NSD2. bioRxiv. 2023 Nov 30. doi: https://doi.org/10.1101/2023.11.01.564830.
November 2023
The Jianping Li Lab opened its door at 802 in the Bluemle Life Sciences Building (BLSB) in the Department of Pharmacology, Physiology, and Cancer Biology at Thomas Jefferson University (TJU) in Philadelphia. Dr. Jianping Li became one of the members of the Blood Cancer Center of Excellence (BCCE) at the NCI-designated Sidney Kimmel Comprehensive Cancer Center (SKCCC) at Jefferson Health.
